GHK-Cu: the copper peptide behind the skincare claims
A three-residue peptide from human plasma that binds copper. Lab data are broad; human data are mostly cosmetic.
What it is
GHK (glycyl-histidyl-lysine) is a tripeptide first identified in human plasma. It binds copper ions tightly, forming GHK-Cu. Levels are reported to fall with age, which is part of why it attracts longevity interest.
What lab studies suggest
Cell and animal studies link GHK-Cu to wound healing, collagen production and antioxidant activity. Analyses of gene-expression databases suggest it may influence many genes involved in tissue repair. These analyses generate hypotheses; they don’t show what happens in a person.
What human studies show
Human data come mainly from small studies of topical skincare products. That’s why GHK-Cu is common as a cosmetic ingredient — and why claims about injected or systemic use run far ahead of the evidence.
Bottom line
Evidence ladder: Human pilot (topical, cosmetic). Not an approved drug.
Sources
Educational content only — not medical advice. See our Medical disclaimer and Editorial policy.